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Targeting the IRAK1-S100A9 Axis Overcomes Resistance to Paclitaxel in Nasopharyngeal Carcinoma.
Liu L, Liu S, Deng P, Liang Y, Xiao R, Tang LQ, Chen J, Chen QY, Guan P, Yan SM, Huang X, Hong JH, Chen J, Sun Y, Teh BT, Yu Q, Mai HQ, Tan J. Liu L, et al. Cancer Res. 2021 Mar 1;81(5):1413-1425. doi: 10.1158/0008-5472.CAN-20-2125. Epub 2021 Jan 5. Cancer Res. 2021. PMID: 33402387
Moreover, both paclitaxel-resistant nasopharyngeal carcinoma cells and relapsed/metastatic clinical samples exhibited increased IRAK1 phosphorylation and demonstrated that pacritinib could abolish the IRAK1 phosphorylation to suppress S100A9 expression. ...To …
Moreover, both paclitaxel-resistant nasopharyngeal carcinoma cells and relapsed/metastatic clinical samples exhibited increased IRAK1 …
Key Genes of Immunity Associated with Pterygium and Primary Sjögren's Syndrome.
Liu Y, Chen H, Cui H. Liu Y, et al. Int J Mol Sci. 2023 Jan 20;24(3):2047. doi: 10.3390/ijms24032047. Int J Mol Sci. 2023. PMID: 36768371 Free PMC article.
The GO and KEGG analyses showed that these common DEGs were enriched in pathways correlated with virus infection, antigen processing and presentation, nuclear factor-kappa B (NF-kappaB) and Th17 cell differentiation. The hub genes (IL1R1, ICAM1, IRAK1, S100A9, and S …
The GO and KEGG analyses showed that these common DEGs were enriched in pathways correlated with virus infection, antigen processing and pre …
Mecp2-null mice provide new neuronal targets for Rett syndrome.
Urdinguio RG, Lopez-Serra L, Lopez-Nieva P, Alaminos M, Diaz-Uriarte R, Fernandez AF, Esteller M. Urdinguio RG, et al. PLoS One. 2008;3(11):e3669. doi: 10.1371/journal.pone.0003669. Epub 2008 Nov 7. PLoS One. 2008. PMID: 18989361 Free PMC article.
Subsequent chromatin immunoprecipitation assays revealed seven direct target genes of Mecp2 bound in vivo (Fkbp5, Mobp, Plagl1, Ddc, Mllt2h, Eya2, and S100a9), and three overexpressed genes due to an indirect effect of a lack of Mecp2 (Irak1, Prodh and Dlk1). ...
Subsequent chromatin immunoprecipitation assays revealed seven direct target genes of Mecp2 bound in vivo (Fkbp5, Mobp, Plagl1, Ddc, Mllt2h, …
Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence.
Goh JY, Feng M, Wang W, Oguz G, Yatim SMJM, Lee PL, Bao Y, Lim TH, Wang P, Tam WL, Kodahl AR, Lyng MB, Sarma S, Lin SY, Lezhava A, Yap YS, Lim AST, Hoon DSB, Ditzel HJ, Lee SC, Tan EY, Yu Q. Goh JY, et al. Nat Med. 2017 Nov;23(11):1319-1330. doi: 10.1038/nm.4405. Epub 2017 Sep 25. Nat Med. 2017. PMID: 28967919
We further show that 1q21.3-encoded S100 calcium-binding protein (S100A) family members, mainly S100A7, S100A8, and S100A9 (S100A7/8/9), and IL-1 receptor-associated kinase 1 (IRAK1) establish a reciprocal feedback loop driving tumorsphere growth. Notably, this func …
We further show that 1q21.3-encoded S100 calcium-binding protein (S100A) family members, mainly S100A7, S100A8, and S100A9 (S100A7/8/ …